ผลงานวิจัย

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ชื่องานวิจัยFatal Adenovirus Inflections in HIV Positive Infants
ชื่อผู้แต่งD. Bhanthumkosol
สถาบันInstitute of Pathology, Department of Medical Service
ที่มาBhanthumkosol D.
คำสำคัญopportunistic infection, adenovirus, infant, pneumonia
ปี พ.ศ.2538
จำนวนหน้า0
ประเภทเอกสารบทคัดย่อ
บทคัดย่อAdenovirus infections occur commonly in infant and children but are rarely fatal. Although immunosuppression has been associated recently with fatal outcome of adenovirus infections ; however, reports of major morbidity or mortality caused by adenovirus infection in HIV positive patients are infrequent. This is the first report of fatal adenovirus infections in HIV-positive infants in Thailand. Three infants, age 4 months, 8 months, and 5 months, were hospitalized with diagnoses of pneumonia and ARDS, pneumonia with hepatomegaly and ARDS, and pediatric AIDS with pneumonia, in 1991, 1992 and 1994, respectively. All infants died within few weeks after hospitalization. Serologic tests, after death and during life, revealed positive anti-HIV in all three infants. Pathological findings, from autopsy and post mortem needle biopsies, revealed adenovirus pneumonia in the first two infants, and massive adenovirus infection of liver in the third infant. Diagnoses were based on characteristic light microscopic findings, and demonstration of viral particles arranged in crystalline arrays by electron microscopy.
 
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