| บทคัดย่อ | Objective : This case control study examined the impact of HIV infection on drug susceptibility, acceptibility, adverse reactions, and treatment outcome of pulmonary tuberculosis (PTB).
Methods : During Jan. - Oct. 93, 88 consecutive HIV-infected patients and 88 matched HIV-seronegative patients with culture-proved, newly-diagnosed PTB were studied. Comparison of two the groups was made, using Chi squared statistic.
Results : Mean age (SD) was 36 (8.8) yrs (82 Males, 6 Females). The resistant rates to antiTB drugs were not different except for Streptomycin, higher among the HIV group (16% vs 5%, p=0.01). Cutaneous hypersensitivity (11%) and drug-induced hepatitis (16%) occured more often in the HIV group, albeit not statistically significant. Default was much higher in the HIV group (33% vs 8%, p<0.001). However, for those completed the treatment, culture conversion rates were satisfactory, approaching 100%, in both regimens employed (2EHRZ/4HR, 2EHRZ/7HR). Twelve HIV-infected patients (14%) died during the course of treatment, 4 of whom as a result of PTB.
Conclusions : Short-course chemotherapy for PTB in HIV-infected patients is as efficacious as in general population. A 6-month protocol comprising 2EHRZ/4HR should be adopted in order to achieve better compliance. |
