ผลงานวิจัย

หมายเลขหนังสือ8
ชื่องานวิจัยUtility of PPD and Anergy Skin Testing in Tuberculosis (TB) Prevention Programs for HIV-Infected Persons
ชื่อผู้แต่งH. Yanai1, Uthaivoravit W., Sawanpanyalert P., Limpakarnjanarat K., Morrow RH. and Mastro TD.
สถาบัน1Ministry of Public Health
ที่มาYanai H., Uthaivoravit W., Sawanpanyalert P., Limpakarnjanarat K., Morrow RH. and Mastro TD. “Utility of PPD and Anergy Skin Testing in Tuberculosis (TB) Prevention Programs for HIV Infected Persons.
คำสำคัญopportunistic infection, TB
ปี พ.ศ.2538
จำนวนหน้า0
ประเภทเอกสารบทคัดย่อ
บทคัดย่อObjectives : To use PPD and anergy skin testing to identify latent M. tuberculosis (M. tb) infection in HIV-infected (HIV+) persons to guide TB preventive therapy programs in Thailand. Methods : We examined reactivity to PPD, mumps, and candida antigen in 216 asymptomatic HIV+ blood donors and 246 HIV-seronegative (HIV-) blood donors. Mantoux procedure was used and induration was measured. Results : Latent M. tb infection (PPD>=10 mm) was common in HIV-persons : 65.6% (108/165) among those with, and 50.6% (41/80) among those without a BCG scar. HIV+ persons had decreased (p<0.01) PPD reactivity : 13%, 21% and 41% had reactivity of >=10mm, >=5mm and >=2mm, respectively. Mean induration to mumps and candida were also reduced : 5.2mm and 5.1mm in HIV+ persons compared to 16.6mm and 7.0mm in HIV-persons (p<0.01), respectively. Cutaneous anergy (<2mm to all 3 antigens) was found in 16.2% (35/216) of HIV+ persons, but only 0.8% (2/244) of HIV- persons (p<0.01). CD4 cell counts and skin test reactivity had some correlation. Conclusions : Skin testing has limited ability to identify latent M. tb infection in HIV+ persons, although mumps and candida are appropriate antigens for anergy testing in Thailand. Our finding of high prevalence of latent M. tb infection in HIV- persons supports the provision of TB preventive therapy to all HIV+ persons in Thailand regardless of PPD and anergy status, if the feasibility and safety of such programs are evaluated and assured.
 
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